QUICK NOTES BASAL CELL CARCINOMA

QUICK NOTES FOR LAST MINUTE PREPARATION:

BASAL CELL CARCINOMA 

OTHER NAME Rodent ulcer

CLINICAL FEATURES

  • Basal cell carcinoma is a disease of adult whites
  • Most prevalent in patients older than 40 years
  • Malesare most commonly affected
  • Incidenceof BCC is high in areas with high temperature and low humidity
  • Site – commonly occurs cover the hair bearing areas of facial skin (especially mucocutaneous areas)
  • Orofacial areas are particularly vulnerable to lesion are upper lip, nasolabial folds, periorbital region,cheek, forehead,ear etc.
  • The most common form of this lesion , the nodular ( noduloulcerative) BCC , begins as a firm, painless papule that slowly enlarges and gradually develops a central depression and an umbilicated appearance
  • The lesion invades the mucous membrane by directly spreading from the adjacent skin
  • It is slow growing, slightly elevated small nodule
  • Eventually develop into central,crusted ulcer with an elevated, smooth- rolled border
  • Lesion heal partially by scarring in central area but it keeps on spreading centrifugally
  • When the lesion is pressed, a characteristic pearly opalescent quality is discerned Expanding ulceration often develops in the central depressed area and and patient gives history of bleeding followed by healing
  • “Rodent ulcer ” name is given to this tumor as it makes a slow but relentless progress and increases in size by invading and destroying adjoining tissues.

HISTOPATHOLOGY:

  • Characteristised by neoplastic proliferation of basaltic epithelial cells in the form of multiple solid islands
  • Cells in periphery of tumor islands are columnar in shape and they often resemble basal layer of oral epithelium with hypercholesterolemia nuclei
  • Tumor cells do not show any feature of abnormal mitosis
  • Central cells of tumor islands may be polyhedral, oval, round or even spindle shaped
  • Basal cell carcinoma sometimes resembles ‘Follicular Ameloblastoma’.

DIFFERENTIAL DIAGNOSIS

  • Ameloblastoma
  • Squamous cell carcinoma

TREATMENT

  • Surgical excision of electrocuted you alongwith radiotherapy
  • Prognosis extremely good
  • Cure rate 95%